The Brumbies make two tweaks to the side that will face the Reds as Fotu Auelua and Tevita Kuridani come in for Jordan Smiler and Andrew Smith.
Clyde Rathbone fills the final spot on the bench.
The Reds present the Brumbies with their biggest challenge of Super Rugby 2013. Brimming with talent, the Reds will carry 279 Test caps onto Suncorp Stadium, with experience spread throughout their forwards, backs and bench.
Adding to the Reds quality are 15 players returning from their 2011 title winning squad, which will be eager to keep the Rod Macqueen Cup in Brisbane for another year. 2012 was the first time the Reds had taken the annual trophy back to Queensland and Brumbies coach Jake White said they would be fighting tooth and nail to keep it there.
"The Reds present us with a massive challenge, but one we need to be able to overcome if we're to progress in this competition," White said.
"For the last three years they've been the team to beat and the side that all other Australian teams have used as a benchmark, so we are fully aware of the challenge that awaits us on Saturday night.
"The Reds are the current Australian Conference champions and it was only 18 months ago they were the Super Rugby champions. They have enough international experience to make things very difficult for us on Saturday night."
Brumbies: 15 Jesse Mogg, 14 Henry Speight, 13 Tevita Kuridani, 12 Christian Lealiifano, 11 Joe Tomane, 10 Matt Toomua, 9 Nic White, 8 Fotu Auelua, 7 George Smith, 6 Ben Mowen, 5 Sam Carter, 4 Peter Kimlin, 3 Dan Palmer, 2 Stephen Moore, 1 Ben Alexander.
Replacements: 16 Siliva Siliva, 17 Scott Sio, 18 Jordan Smiler, 19 Colby Faingaa, 20 Ian Prior, 21 Pat McCabe, 22 Clyde Rathbone.
Date: Saturday, April 20
Kick-off: 19:40 local (10:40 BST, 09:40 GMT)
Venue: Suncorp Stadium, Brisbane
Referee: Glen Jackson (New Zealand)
Assistant referees: Steve Walsh (Australia), James Leckie (Australia)
Television match official: Steve Leszczynski (Australia)