Leicester Tigers wing Niall Morris' season could be over due to a hand injury which required surgery.
Morris could be sidelined for between eight to 12 weeks. If he is out for the latter date, it means he will only be available for selection in late April, with Leicester's final league match of the season scheduled for May 10.
He is joined on the long-term injury list by fellow flyer Miles Benjamin, who is due to miss between four and six weeks with a knee injury which also requires an operation.
The duo's injuries the latest setback for Tigers' director of rugby Richard Cockerill, whose side has been decimated by injuries all season.
"Niall Morris has had his thumb operated on that was repeatedly dislocated against Ulster, and he will be out for eight to 12 weeks," Cockerill told the Leicester Mercury.
"He has had that wired and we will see how that goes. That's obviously disappointing.
"It now needs to be fixed and that is what we have done.
"Benjamin is having a wash-out on that knee injury he picked up at Treviso, so he is probably going to be six weeks. There was a little bit of debris in there."
With Adam Thompstone called up to the England Saxons squad, and Gonzalo Camacho out until March with a shoulder injury, Leicester will face Bath in Friday's LV= Cup clash without their four front-line wings.
19-year-old Henry Purdy is also unavailable as England have first call on his services for the U20 Six Nations while Harry Thacker (hooker) and Will Owen (back row) are also in that squad.
There is good news, however, as some of Leicester's injured stalwarts are closing in on a return to action.
"Mat Tait (back) is coming on well and will be good to train again next week," added Cockerill.
"Graham Kitchener (knee) will be fit next week and Jordan Crane (shoulder) won't be long.
"Logovi'i Mulipola will be fit for the Worcester game in the Premiership, if not this week, while David Mele was fine after a bang on the hip against Harlequins.
"We are getting some guys back but, as ever, we lose people at the same time."