Wasps full-back Elliot Daly will make his first appearance of this season in his side's clash with Worcester at Adams Park on Saturday.
The highly talented 20-year-old's return to the starting XV is timely given injuries to experienced Wasps backs Tom Varndell, Hugo Southwell and Andrea Masi, and Dai Young has handed the England Saxon the number 15 shirt from the off this Saturday.
Daly's return is one of two changes to to director of rugby Dai Young's starting line-up, with Nathan Hughes starting his first game for the club at number eight, having impressed off the bench last time out. He takes the place of Ed Jackson, who misses out through illness.
On the bench, Jack Moates is poised for his first Wasps appearance, with Joe Simpson ruled out as a precaution after taking a knock to the head last weekend.
Young said: "We've worked really hard this week on the areas that have been letting us down and it's time for us to start converting the narrow losses into wins.
"Everyone is looking forward to our first game back at Adams Park and hopefully getting off to a good home start."
Meanwhile, George Porter will make his first Warriors appearance in over nine months after being named at loosehead prop for the clash with Wasps.
It will be the 24-year-old's second Aviva Premiership start for Warriors after he was ruled out for most of last season.
Euan Murray and Chris Jones are recalled to the side as Warriors and Wasps both search for their first win of the campaign.
Semisi Taulava will add firepower at number eight in a back row also featuring captain Jonathan Thomas and Jake Abbott.
New signing Dean Hammond is handed a place on the bench while Chris Brooker could also make his Aviva Premiership return from the bench.
Worcester director of rugby Dean Ryan said: "We've got a game against a side that are struggling to get results as well so whoever gets one this weekend will be pretty pleased.
"Then we've got Newcastle back at Sixways so we've just got to keep working and getting better.
"There's a real tendency to pull everything apart but we've played two of the top sides in our first three games.
"We have got to understand where we are and we have to ensure when we get into those games where we can be a little more competitive, we are more clinical and get the win.
"There will be pace and intensity from Wasps and Christian Wade. If we can't cope with the pace he will get the chance to come over the top of us.
"If we can get a bit more control of the game we will see a bit more of our attacking game."
Form: London Wasps have lost their last eleven fixtures in all competitions, and have never before begun a league campaign with four successive defeats. Worcester Warriors have lost their last eight matches, since beating Wasps 29-23 at Sixways on 1st March. The Warriors have not won away from home in Aviva Premiership Rugby since they visited Adams Park on New Year's Day 2012 and beat their hosts 6-0.
Wasps: 15 Elliot Daly, 14 Christian Wade, 13 Ben Jacobs, 12 Chris Bell (c), 11 Josh Bassett, 10 Andy Goode, 9 Charlie Davies, 8 Nathan Hughes, 7 Sam Jones, 6 Ashley Johnson, 5 Kearnan Myall, 4 Joe Launchbury, 3 Jake Cooper-Woolley, 2 Carlo Festuccia, 1 Matt Mullan.
Replacements: 16 Tom Lindsay, 17 Simon McIntyre, 18 Will Taylor, 19 Tom Palmer, 20 Guy Thompson, 21 Jack Moates, 22 Joe Carlisle, 23 Charlie Hayter.
Worcester: 15 Chris Pennell, 14 Josh Drauniniu, 13 Ravai Fatiaki, 12 Josh Matavesi, 11 David Lemi, 10 Ignacio Mieres, 9 Paul Hodgson, 8 Semisi Taulava, 7 Jake Abbott, 6 Jonathan Thomas (c), 5 Chris Jones, 4 Mike Williams, 3 Euan Murray, 2 Ed Shervington, 1 George Porter.
Replacements: 16 Chris Brooker, 17 Paul Andrew, 18 John Andress, 19 Dean Schofield, 20 Sam Betty, 21 Jeremy Su'a, 22 Danny Gray, 23 Dean Hammond.
Date: Saturday, September 28
Kick-off: 15:00 BST
Venue: Adams Park
Referee: Gregory Garner
Assistant referees: Roy Maybank, Andrew Pearce
Television match official: David Grashoff
Timekeeper: Robert Ockenden