Toulouse will be looking to secure a home Heineken Cup quarter-final as they travel to Parma to face Zebre on Saturday.
Victory at Stadio XXV Aprile would be enough to ensure top spot in Pool 3 but, depending a results elsewhere, the French giants may need a bonus point to be sure of hosting a playing-off.
The big news for Toulouse is the return of Heineken Cup all-time top try scorer Vincent Clerc in a starting XV that features four changes to the side that beat Saracens last week.
With Clerc back, Yoann Huget switches wings to start on the left as Hosea Gear drops out of the squad.
Gael Fickou is promoted to the starting line-up at 12 with Clement Poitrenaud moving to the bench. At scrum-half, Sebastian BÃ©zy starts in a straight swap with Jano Vermaak.
In the pack, Joe Tekori is named in the second row as Patricio Albacete is given a rest.
Prop Cyril Baille and Fijian flyer Timoci Matanavou are added to the replacements.
There are five changes to the Zebre team that lost away to Connacht last week as former All Black Brendon Leonard returns at scrum-half and Mauro Bergamasco comes in at flank.
Zebre: 15 Ruggero Trevisan, 14 Leonardo Sarto, 13 Kameli Ratuvou, 12 Gonzalo Garcia, 11 Dion Berryman, 10 Luciano Orquera, 9 Brendon Leonard, 8 Samu Vunisa 7 Dries van Schalkwyk, 6 Mauro Bergamasco, 5 George Biagi, 4 Quintin Geldenhuys (c), 3 Dario Chistolini, 2 Tommaso D'Apice , 1 Matias Aguero.
Replacements:16 Luciano Leibson, 17 Andrea de Marchi, 18 Luca Redolfini, 19 Emiliano Caffini, 20 Filippo Cristiano, 21 Alberto Chillon, 22 Roberto Quartaroli, 23 Gullo
Toulouse: 15 Maxime MÃ©dard, 14 Vincent Clerc, 13 Yann David, 12 Gael Fickou, 11 Yoann Huget, 10 Jean-Marc Doussain, 9 Sebastian BÃ©zy, 8 Louis Picamoles, 7 Thierry Dusautoir (c), 6 Yannick Nyanga, 5 Joe Tekori, 4 Yoann Maestri, 3 Census Johnston, 2 Chiliboy Ralepelle, 1 Schalk Ferriera.
Replacements: 16 Christopher Tolofua, 17 Cyril Baille, 18 Yohan Montes, 19 Romain Millo-Chluski, 20 Yacouba Camara, 21 Jano Vermaak, 22 Clement Poitrenaud, 23 Timoci Matanavou .
Date: Saturday, January 18
Kick-off: 14:35 local (13:35 GMT)
Venue: Stadio XXV Aprile
Referee: Dudley Phillips (Ireland)
Assistant referees: Eddie Hogan-O'Connell (Ireland), Paul Haycock (Ireland)
Television match official: Marshall Kilgore (Ireland)