Munster and Ireland winger Simon Zebo will play no part in the upcoming November Internationals after breaking his foot.
Zebo was withdrawn during Munster's 23-29 loss to Edinburgh last weekend in the second half.
The ten-week schedule required to bring Zebo back to full fitness means he will miss Ireland's Test matches against Samoa, Australia and New Zealand.
His participation in key Heineken Cup games for Munster against Gloucester at home this weekend and then a double-header with Perpignan in December has also been ruled out.
Zebo missed the remainder of last season's Six Nations campaign with another foot injury, before recovering to be called for the British and Irish Lions tour of Australia.
"Simon Zebo has been ruled out of action for approximately ten weeks following on from the injury he picked up in Saturday's opening Heineken Cup game against Edinburgh," said a statement on the Munster website.
"A scan carried out earlier today has identified a crack in a bone in his left foot and Zebo will continue to wear the medical boot he was issued post-match for the next four weeks, and will be side-lined for approximately ten weeks."