Munster will be aiming to win and score at least four tries against Edinburgh on Sunday to stay in the hunt for a Heineken Cup quarter-final berth.
The two-time champions (2006 and 2008) trail Pool 1 leaders Saracens by three points and are one behind Racing Metro, who host Sarries on Saturday.
A full house of points in the Scottish capital for Munster will set up a showdown with against Racing Metro at Thomond Park next week.
The Irish giants, who are looking to bounce back from defeat to Cardiff Blues at Musgrave Park last week, have only failed to reach the last eight of European rugby's premier tournament once in the last 14 seasons, back in 2011.
Edinburgh are out of this season's tournament and are still looking for their first points. The Scottish team have lost their last five matches, including last season's semi-final. This season, they have been nilled twice and are yet to hit double figures in a single game.