Leicester have made six changes to their starting XV that will face Treviso at Stadio di Monigo on Saturday.
Anthony Allen returns to the line-up after missing the home win in Round 3 due to an injury in the Premiership match against Bath a week earlier.
Niall Morris and Adam Thompstone return on the wings, while Dan Cole, Louis Deacon and Brett Deacon are recalled into the forward pack.
Logovi'i Mulipola is selected among the replacements on his return from injury.
Meanwhile, Treviso have named their strongest available side and enter with confidence after pushing the Tigers close last weekend thanks to a strong second-half showing at Welford Road.
Christian Loamanu and Alberto Sgarbi come into the centre positions while Alberto Di Bernardo, Alessandro Zanni, Cornelius van Zyl, Francesco Minto, Lorenzo Cittadini, Leonardo Ghiraldini and Michele Rizzo also get starts on Saturday.
Treviso: 15 Luke McLean, 14 Ludovico Nitoglia, 13 Christian Loamanu, 12 Alberto Sgarbi, 11 Tommaso Iannone, 10 Alberto Di Bernardo, 9 Edoardo Gori, 8 Manoa Vosawai, 7 Dean Budd, 6 Alessandro Zanni, 5 Cornelius van Zyl, 4 Francesco Minto, 3 Lorenzo Cittadini, 2 Leonardo Ghiraldini, 1 Michele Rizzo.
Replacements: 16 Franco Sbaraglini, 17 Matteo Muccignat, 18 Ignacio Fernandez Rouyet, 19 Valerio Bernabo, 20 Paul Derbyshire, 21 Simone Favaro, 22 Fabio Semenzato, 23 Kristopher Burton.
Leicester: 15 Mathew Tait, 14 Niall Morris, 13 Manu Tuilagi, 12 Anthony Allen, 11 Adam Thompstone, 10 George Ford, 9 Ben Youngs, 8 Thomas Waldrom, 7 Julian Salvi, 6 Brett Deacon, 5 Geoff Parling, 4 Louis Deacon, 3 Dan Cole, 2 Tom Youngs, 1 Marcos Ayerza.
Replacements: 16 George Chuter, 17 Logovi'i Mulipola, 18 Martin Castrogiovanni, 19 Graham Kitchener, 20 Jordan Crane, 21 Sam Harrison, 22 Geordan Murphy, 23 Dan Bowden.
Date: Saturday, December 15
Kick-off: 14:35 (13:35 GMT)
Venue: Stadio di Monigo
Referee: Alain Rolland (Ireland)
Assistant referees: Shaun Gallagher (Ireland), Olly Hodges (Ireland)
Television match official: Marshall Kilgore (Ireland)