Saracens have named Owen Farrell at outside centre for their second Pool game of the 2012/13 Heineken Cup, against Racing-Metro on Saturday.
Saracens will create history in becoming the first club to stage a European match in Brussels.
Racing are the visitors to the Stade Roi Baudouin for the clash with both teams having recorded wins in their opening matches in the competition.
In team news ahead of the game in Belgium, Chris Wyles will make his 100th appearance for Saracens and becomes the latest member of the 100 club. Wyles starts the game at wing and will lead the team out in recognition of his milestone.
Other changes to the side that beat Edinburgh 45-0 last week sees Farrell start at outside centre while Neil de Kock is named at scrum-half.
Alistair Hargreaves and Carlos Nieto come onto the bench with Joel Tomkins, Richard Wigglesworth and David Strettle named in the 23.
Meanwhile, Racing have recalled Juan Martin Hernandez after the Argentina star missed last week's victory over Munster. He starts at 15 alongside Benjamin Fall and Juan Imhoff.
There is a change at eight where Bernard le Roux is preferred over Masinivanua Matadigo.
Rugby Union betting odds
Saracens: 15 Alex Goode, 14 Chris Ashton, 13 Owen Farrell, 12 Brad Barritt, 11 Chris Wyles, 10 Charlie Hodgson, 9 Neil de Kock, 8 Jackson Wray, 7 Will Fraser, 6 Kelly Brown, 5 Mouritz Botha, 4 Steve Borthwick, 3 Matt Stevens, 2 Schalk Brits, 1 Rhys Gill.
Replacements: 16 John Smit, 17 Mako Vunipola, 18 Carlos Nieto, 19 Alistair Hargreaves, 20 Andy Saull, 21 Richard Wigglesworth, 22 Joel Tomkins, 23 David Strettle.
Racing Metro: 15 Juan Martin Hernandez, 14 Benjamin Fall, 13 Mirco Bergamasco, 12 Fabrice Estebanez, 11 Juan Imhoff, 10 Olly Barkley, 9 Maxime Machenaud, 8 Bernard le Roux, 7 Jacques Cronje (capt), 6 Antoine Battut, 5 Francois Van Der Merwe, 4 Karim Ghezal, 3 Luc Ducalcon, 2 Dimitri Szarzewski, 1 Andrea Lo Cicero.
Replacements: 16 Benkjamin Noirot, 17 Eddy Ben Arous, 18 Juan Pablo Orlandi, 19 Fabrice Metz, 20 Julien JanÃ©, 21 Masinivanua Matadigo, 22 Sebastien Descons, 23 Gaetan Germain.
Date: Saturday, October 20
Venue: King Baudouin Stadium, Brussels
Kick-off: 16.40 local (15.40 BST / 14.40 GMT)
Referee: Nigel Owens