Tighthead prop Juan Figallo will play no part in Argentina's match against Australia on Saturday due to a back injury.
The Montpellier forward has been in hugely impressive form throughout The Rugby Championship, winning praise from all quarters for his work as part of an effective Argentinian pack in the scrum.
Figallo has been replaced in the side by Racing Métro man Juan Pablo Orlandi, with Matias Diaz coming onto the bench.
There are no other changes to the side as Argentina seek to pick up their first ever win in the tournament against the Wallabies in Rosario.
Argentina: 15 Juan Martin Hernandez, 14 Horacio Agulla, 13 Marcelo Bosch, 12 Felipe Contepomi, 11 Juan Imhoff, 10 Nicolas Sanchez, 9 Martin Landajo, 8 Juan Manuel Leguizamon, 7 Pablo Matera, 6 Juan Martin Fernandez Lobbe (captain), 5 Patricio Albacete, 4 Julio Farias Cabello, 3 Juan Pablo Orlandi, 2 Eusebio Guinazu, 1 Marcos Ayerza.
Replacements: 16 Agustin Creevy, 17 Nahuel Lobo, 18 Matias Diaz, 19 Manuel Carizza, 20 Benjamn Macome, 21 Tomas Cubelli, 22 Santiago Fernandez, 23 Lucas Gonzalez Amorosino.
Date: Saturday, October 5
Kick-off: 19:40 (23:40 BST, 22:40 GMT)
Venue: Gigante de Arroyito Stadium, Rosario