Brumbies centre Tevita Kuridrani will make his first start for Australia against South Africa in Cape Town, according to reports.
Kuridrani is set to be named as one of six changes to the side that defeated Argentina in Perth two weeks ago.
The Fijian-born 22-year-old will come into the midfield to partner club team-mate Christian Lealiifano, with Adam Ashley-Cooper moving to the right wing in place of the suspended James O'Connor.
An injury to Nick Cummins means a recall for Joe Tomane on the opposite wing, while Nic White is set to keep the scrum-half spot ahead of Reds number nine Will Genia.
The key change however arguably comes in the second row, where James Horwill will return to lead the side.
Alterations to Australia's replacements will see the inclusion of prop Benn Robinson and winger Chris Feauai-Sautia.
Hooker Stephen Moore outlined the obvious tactics South Africa would implement on Saturday, praising them for their execution.
"If they're talking about playing us, they're talking about bashing us physically and not too much else outside of that," Moore told the Daily Telegraph.
"They're talking about field position, getting penalties, building a score with [Morne] Steyn being a very accurate goal kicker. And then when they get into our half they're going to look to drive when they get opportunities. The game plan will be pretty simple, they just do it quite well."