Back-rower Ben Mowen will become Australia's 80th Test captain in Saturday's Test against Argentina in Perth after Will Genia was dropped from the starting XV.
Mowen takes over the captaincy less than three months after debuting against the British and Irish Lions in June and in just his seventh Test for the Wallabies.
Mowen's ascendency comes earlier than expected with James Horwill currently sidelined through injury and Brumbies team-mate Nic White winning his first run-on Test cap at scrum-half in place of Genia.
White has played all three of his Tests from the bench since debuting against New Zealand in Sydney last month and has now earned the right to wear the Wallabies number nine jersey for the first time.
His selection in the starting XV caps off a stellar year for the 23-year-old, who also played an influential role in the Brumbies' Super Rugby campaign and also in their historic victory over the British and Irish Lions.
The change at scrum-half is one of four made to Wallabies coach Ewen McKenzie's squad with Ben Alexander also regaining his place at tighthead prop.
Powerful 125kg Waratahs lock Sitaleki Timani will bring size in his return to the Australian fold and has been included on a bench which also includes Brumbies outside back Tevita Kuridrani.
McKenzie said it was tough to bench Genia but also believed White had earned an opportunity to start against Argentina.
"The fact that Will has captained his country shows what high regard we hold him in and while he is naturally disappointed I also know how competitive he is and I've got no doubts he will train himself to a standstill to bounce back as a better player," McKenzie said.
"We've spoken about what areas we believe he can continue to improve and evolve his game and he was receptive to going back and addressing those things.
"In the end, it wasn't an easy decision because he is undoubtedly a world class player.
"However, we also feel Nic has earned an opportunity to start and will add his own uniqueness and point of difference to how we want to play this game.
"Nic has had a great season with the Brumbies and has brought his own brand of energy and hard work to the Wallaby group.
"We've all been impressed by the contributions he has made to the team and in training and we now look forward to seeing him bring his skills to the fore of the pressure cooker on Saturday night."
The Wallabies are spending the week in Perth, where they will be aiming to capture their first victory of the Rugby Championship against a vastly-improved Argentinian side.
McKenzie said he was disappointed by the performances of the Wallabies to this point but was confident they could turn it around by adjusting some elements of their gameplan.
"We made it clear before our first game against New Zealand that this group had very strong ideas around how they wanted to approach and play each game," he said.
"Australian Rugby is renowned for smart, attractive and running rugby and there is a continued determination from the coaching staff and players to play with ambition and flair. We aren't moving away from this philosophy.
"Within this framework though we've worked hard during the week to provide the team with further clarity on certain areas to ensure we are making smarter decisions in different parts of the field.
"By doing this we will endeavour to remove some of the pressure we are applying on ourselves and shift that pressure to the opposing team.
"Rugby is a game of chess and we will look forward to the challenge of getting the right balance and our first Rugby Championship win."
Australia: 15 Israel Folau, 14 James O'Connor, 13 Adam-Ashley Cooper, 12 Christian Lealiifano, 11 Nick Cummins, 10 Quade Cooper, 9 Nic White, 8 Ben Mowen (c), 7 Michael Hooper, 6 Scott Fardy, 5 Kane Douglas, 4 Rob Simmons, 3 Ben Alexander, 2 Stephen Moore, 1 James Slipper.
Replacements: 16 Saia Faingaa, 17 Scott Sio, 18 Sekope Kepu, 19 Sitaleki Timani, 20 Ben McCalman, 21 Will Genia, 22 Matt Toomua, 23 Tevita Kuridrani.
Date: September 14
Venue: Patersons Stadium, Perth
Kick-off: 18:05 (10:05 GMT)
Referee: Nigel Owens (Wales)
Assistant referees: George Clancy (Ireland), Glen Jackson (New Zealand)
Television match official: Vinny Munro (New Zealand)
Assessor: Tappe Henning