France coach Philippe Saint-André has made three changes to his starting XV to play Scotland, with Mathieu Bastareaud starting in midfield.
Two more changes see young Perpignan lock Sebastien Vahaamahina win a first start to partner Yoann Maestri in the engine room, with Castres forward Antonie Claassen at blindside flanker.
The South African-born forward makes his first start for Les Bleus following two appearances off the bench against England and Ireland.
Those changes mean that Christophe Samson and Yannick Nyanga drop to the bench, whilst either Florian Fritz or Toulouse star Gael Fickou will fill the 23 jersey.
Fritz is a doubt because of a foot injury and has been given till Friday to prove his fitness.
France come into their final fixture against Scotland bottom of the Six Nations table, with three losses and one draw to their name.
France: 15 Yoann Huget, 14 Vincent Clerc, 13 Mathieu Bastareaud, 12 Wesley Fofana, 11 Maxime Médard, 10 Frederic Michalak, 9 Morgan Parra, 8 Louis Picamoles, 7 Thierry Dusautoir, 6 Antonie Claassen, 5 Yoann Maestri, 4 Sebastien Vahaamahina, 3 Nicolas Mas, 2 Benjamin Kayser, 1 Thomas Domingo.
Replacements: 16 Guilhem Guirado, 17 Vincent Debaty, 18 Luc Ducalcon, 19 Christophe Samson, 20 Yannick Nyanga, 21 Maxime Machenaud, 22 Francois Trinh-Duc, 23 Florian Fritz or Gael Fickou.
Date: Saturday, 16 March
Venue: Stade de France, Paris
Kick-off: 22:00 local (20:00 GMT)
Referee: Nigel Owens (Wales)
Assistant referees: George Clancy (Ireland), Lourens van der Merwe (South Africa)
Television match official: Carlo Damasco (Italy)