Ronan O'Gara is the big name missing from Ireland's 32-man squad for the Six Nations match against France in Dublin.
The veteran fly-half has struggled to find his rhythm in recent months, with Paddy Jackson getting the nod ahead of him for the defeat by Scotland following Jonathan Sexton's withdrawal due to injury.
The omission may well signal the end for Ireland's most-capped player at international level, with the last of his 128 appearances coming as a substitute during the Scotland game.
Although Sexton has not yet fully recovered, he has not yet been ruled out of Saturday's game at the Aviva Stadium, but Jackson and Ian Madigan are both in the squad as cover.
Sexton is not the only one struggling with injury as locks Mike McCarthy and Donnacha Ryan as well as wing Craig Gilroy are also under a cloud despite being included in the squad.
Gordon D'Arcy is still struggling with a foot injury and is ruled out alongside fellow centre Darren Cave and utility player Robbie Henshaw.
However, Andrew Trimble is back in the squad having been overlooked since the autumn internationals, with Robbie Diack selected for a Six Nations squad for the first time.
Ireland squad: Rory Best, Sean Cronin, Robbie Diack, Keith Earls, Luke Fitzgerald, Declan Fitzpatrick, Craig Gilroy, Cian Healy, Jamie Heaslip, Iain Henderson, Paddy Jackson, Dave Kearney, Rob Kearney, David Kilcoyne, Ian Madigan, Luke Marshall, Mike McCarthy, Fergus McFadden, Conor Murray, Sean O'Brien, Donncha O'Callaghan, Tommy O'Donnell, Brian O'Driscoll, Peter O'Mahony, Eoin O'Malley, Eoin Reddan, Mike Ross, Donnacha Ryan, Jonathan Sexton, Andrew Trimble, Devin Toner Dan Tuohy.