Ireland head coach Declan Kidney has revealed that wing Simon Zebo will be sidelined for ten weeks after breaking a bone in his foot against England.
Zebo, who went off in the tenth minute of an bruising contest and was replaced by utility Keith Earls, is now set to undergo surgery on Monday.
As well as the rest of the Championship, which finishes on March 16, Zebo is also in line to be ruled out of Munster's Heineken Cup quarter-final away to English champions Harlequins on April 7.
Ireland coach Declan Kidney, who confirmed the extent of Zebo's injury, had slightly better news regarding the rest of a growing casualty list.
He estimated fly-half Jonathan Sexton, who went off against England after half an hour with a hamstring injury and was replaced by Ronan O'Gara, would be out for two weeks.
Flanker Sean O'Brien (tight hamstring), lock Mike McCarthy (knee ligament strain), centre Brian O'Driscoll (twisted ankle) and lock Donnacha Ryan (back) also sustained injuries, but have yet to be ruled out of Ireland's next Six Nations match, away to Scotland on February 24.
"Simon will have surgery tomorrow (Monday). Johnny will have a scan either later tonight or tomorrow," said Kidney. "It looks like a couple of weeks for Johnny, but it would be wrong to try and second guess the outcome. We'll know more by Tuesday.
"It's been an attritional couple of games and we had a few injuries leading into the tournament, but that's the way it goes."