Ospreys forward Ryan Jones will captain Wales from blindside flanker against France at the Stade de France on Saturday.
Regular captain Sam Warburton has been ruled out through injury, meaning Justin Tipuric has been brought in at openside to partner Jones.
The other change sees Ospreys hooker Richard Hibbard earn a start, with Matthew Rees dropping out of the 22 through injury.
Scarlets second-row Lou Reed earns a spot amongst the replacements ahead of Harlequins' Olly Kohn, with Aaron Shingler dropping to the bench.
Wales: 15 Leigh Halfpenny, 14 Alex Cuthbert, 13 Jonathan Davies, 12 Jamie Roberts, 11 George North, 10 Dan Biggar, 9 Mike Phillips, 8 Toby Faletau, 7 Justin Tipuric, 6 Ryan Jones (c), 5 Ian Evans, 4 Andrew Coombs, 3 Adam Jones, 2 Richard Hibbard, 1 Gethin Jenkins.
Replacements: 16 Ken Owens, 17 Paul James, 18 Craig Mitchell, 19 Lou Reed, 20 Aaron Shingler, 21 Lloyd Williams, 22 James Hook, 23 Scott Williams.
Date: Saturday, February 9:
Venue: Stade de France
Kick-off: 18.00 local (17.00 GMT)
Referee: George Clancy (Ireland)
Assistant referees: Alain Rolland (Ireland), Francisco Pastrana (Argentina)
Television match official: Giulio De Santis (Italy)