Centres Manu Tuilagi, Brad Barritt and Billy Twelvetrees have all been included in England's 25-man squad to face Ireland.
Uncapped Wasps number eight Billy Vunipola is also in contention to replace Ben Morgan, who has not been included in the travelling party after suffering a sprained ankle against Scotland.
Morgan will remain with the England squad to continue treatment and, although not officially ruled out, the Gloucester forward is a major doubt for the clash at Aviva Stadium.
James Haskell is expected to be promoted into the starting line-up at blindside flanker, with Tom Wood set to shift across the back row to replace Morgan and Vunipola or Thomas Waldrom expected to be named on the bench.
Seven players - Mouritz Botha, Freddie Burns, Ben Foden, Lee Dickson, Will Fraser, Jonathan Joseph and Matt Kvesic - have been released from the squad and will not take part against Ireland.
England are permitted under the terms of their agreement with Premiership Rugby to travel to away games with two additional players to their 23-man match-day squad. Lancaster will confirm the match-day selection on Friday.
England squad to face Ireland:
Backs: Chris Ashton (Saracens), Brad Barritt (Saracens), Mike Brown (Harlequins), Danny Care (Harlequins), Owen Farrell (Saracens), Toby Flood (Leicester), Alex Goode (Saracens), David Strettle (Saracens), Manu Tuilagi (Leicester), Billy Twelvetrees (Gloucester), Ben Youngs (Leicester).
Forwards: Dan Cole (Leicester), Dylan Hartley (Northampton), James Haskell (Wasps), Joe Launchbury (Wasps), Courtney Lawes (Northampton), Joe Marler (Harlequins), Geoff Parling (Leicester), Chris Robshaw (Harlequins, capt), Billy Vunipola (Wasps), Mako Vunipola (Saracens), Thomas Waldrom (Leicester), David Wilson (Bath), Tom Wood (Northampton), Tom Youngs (Leicester).