England have included uncapped Gloucester centre Billy Twelvetrees in their 23-man squad for the Six Nations opener with Scotland on Saturday.
With Manu Tuilagi out injured, 24-year-old Twelvetrees has been preferred to London Irish outside centre Jonathan Joseph, who has been sent back to his club.
Saracens wing David Strettle has also been included, but there is no place in the squad for Northampton full-back Ben Foden.
England head coach Stuart Lancaster will confirm his starting XV on Thursday.
Mouritz Botha, who has revealed he is heading to New York "for the rest of the week", Thomas Waldrom, Lee Dickson, Billy Vunipola, Ugo Monye, Henry Thomas and Matt Kvesic were the other players released
"We've had to make some tough calls with a lot of competition for places," Lancaster.
"The players' attitude and application in training has been first rate and we know those going back to their clubs and playing in the LV= Cup will be pushing hard for contention for the Ireland match."
Forwards (13): Dan Cole, Dylan Hartley, James Haskell, Joe Launchbury, Courtney Lawes, Joe Marler, Ben Morgan, Geoff Parling, Chris Robshaw, Mako Vunipola, David Wilson, Tom Wood, Tom Youngs,
Backs (10): Chris Ashton, Brad Barritt, Mike Brown, Danny Care, Owen Farrell, Toby Flood, Alex Goode, David Strettle, Billy Twelvetrees, Ben Youngs.
Players released: Mouritz Botha, Lee Dickson, Ben Foden, Jonathan Joseph, Matt Kvesic, Ugo Monye, Henry Thomas, Billy Vunipola, Thomas Waldrom