France centre Gael Fickou has been ruled out for a month with an ankle injury, meaning he will miss the start of the Six Nations.
The 18-year-old sustained the injury after coming on as a replacement in Toulouse's 35-14 win over Treviso in the Heineken Cup on Sunday.
It means he will miss the pre-Six Nations training camp with the French squad and also Les Bleus' first two matches against Italy on 3 February and Wales six days later.
He will also be sidelined for Sunday's crucial Heineken Cup clash at Leicester, with the winner progressing to the knockout round.
"Verdict: 4 weeks out, twisted ankle (external ligament), that's part of the game!" said Fickou in a tweet.