Springbok flank Willem Alberts and fly-half Morne Steyn have both been passed fit for Sunday's Test against Scotland at Murrayfield in Edinburgh.
Both players sat out training sessions during the week but took full part in Saturday's captain's run at Murrayfield.
As a result, flanker Siya Kolisi misses out on selection, while Steyn will start from the bench.
South Africa: 15 Willie Le Roux, 14 JP Pietersen, 13 Jaque Fourie, 12 Jean de Villiers (c), 11 Bryan Habana, 10 Patrick Lambie, 9 Fourie du Preez, 8 Duane Vermeulen, 7 Willem Alberts, 6 Francois Louw, 5 Flip van der Merwe, 4 Bakkies Botha, 3 Frans Malherbe, 2 Adriaan Strauss, 1 Gurthrö Steenkamp.
Replacements: 16 Bismarck du Plessis, 17 Tendai Mtawarira, 18 Coenie Oosthuizen, 19 Eben Etzebeth, 20 Marcell Coetzee, 21 Ruan Pienaar, 22 Morné Steyn, 23 JJ Engelbrecht.
Date: Sunday, November 17
Venue: Murrayfield, Edinburgh
Kick-off: 15:00 GMT (17.00 SAST)
Weather: 6°C. Chances of rain.
Referee: Jérôme Garcès (France)
Assistant referees: Pascal Gauzère (France), Dudley Phillips (Ireland)