France head coach Bernard Laporte has announced his team to face Namibia for the Pool D match at the Stade Municipal in Toulouse on Sunday.
Only three players - Cédric Heymans, Damien Traille and Pieter De Villiers - remain from the side shocked 17-12 by Argentina in Friday's tournament opener.
Heymans moves from full-back to wing, with Clément Poitrenaud being handed the number 15 shirt.
There are also opportunities for fly-half Frédéric Michalak, lock Sébastien Chabal, flanker Yannick Nyanga and number eight Julien Bonnaire.
"We know we have to win our next three games against, Nambia, Ireland and Georgia and pick up all the bonus points available," Laporte said.
"The game against Namibia will not be an easy one. We have to set the record straight.
"We know we have to win our next three games against, Nambia, Ireland and Georgia and pick up all the bonus points available.
"The game against Namibia will not be an easy one. We have to set the record straight."
Jean-Baptiste Elissalde will lead the side whilst Raphaël Ibañez - "the natural leader of the team" - looks on from the bench.
"Raphaël is not 25 any more and we have to spare him," added Laporte.
An anticipated bonus-point victory for France would keep them in the quarter-final hunt, although Namibia proved a tough nut for Ireland to crack last weekend, losing just 32-17 in Bordeaux.
France: 15 Clément Poitrenaud,14 Vincent Clerc, 13 David Marty, 12 Damien Traille,11 Cédric Heymans, 10 Frédéric Michalak, 9 Jean-Baptiste Elissalde (c), 8 Julien Bonnaire, 7 Thierry Dusautoir, 6 Yannick Nyanga, 5 Lionel Nallet, 4 Sébastien Chabal, 3 Pieter de Villiers, 2 Dimitri Szarzewski, 1 Jean-Baptiste Poux.
Replacements: 16 Raphaël Ibañez, 17 Nicolas Mas, 18 Fabien Pelous, 19 Imanol Harinordoquy, 20 Lionel Beauxis, 21 Yannick Jauzion, 22 Aurélien Rougerie.
Date: Sunday, 16 September
Venue: Stade Municipal, Toulouse
Kick-off: 21:00 (19:00 GMT)
Referee: Alain Rolland
Touch judges: Carlo Damasco, Kelvin Deaker
Television match official: Simon McDowell
Assessor: Tappe Henning