Ireland coach Joe Schmidt has made eight personnel changes to his side for Saturday's second Test against Argentina in Tucumán.
There is also one positional switch compared to the starting XV that beat the Pumas 29-17 in Resistencia last weekend.
Leinster flank Rhys Ruddock will make his first start for Ireland, winning his third cap in a back row that sees the return on Jamie Heaslip at number eight as Robbie Diack drops out of the matchday squad.
Devin Toner comes back into the second row, ahead of Iain Henderson.
Munster prop Dave Kilcoyne is set for his second start in 10 Tests in the front row as Jack McGrath drops to the bench.
Rob Kearney replaces Felix Jones at full-back.
Fergus McFadden is promoted from the bench to wear the number 13 jersey with Darren Cave switching to inside centre. It will be McFadden's first start at outside centre since the 2012 Six Nations game against Wales
Eoin Reddan comes in at scrum-half some seven years on from his first Test start in green during the 2007 tour to Argentina
There are three uncapped players on the replacements bench: Ulster hooker Rob Herring, Munster prop James Cronin and Leinster's Noel Reid
Ireland: 15 Rob Kearney, 14 Andrew Trimble, 13 Fergus McFadden, 12 Darren Cave, 11 Simon Zebo, 10 Jonathan Sexton, 9 Eoin Reddan, 8 Jamie Heaslip, 7 Chris Henry, 6 Rhys Ruddock, 5 Paul O'Connell, 4 Devin Toner, 3 Mike Ross, 2 Rory Best , 1 Dave Kilcoyne
Replacements:16 Rob Herring, 17 James Cronin, 18 Jack McGrath, 19 Iain Henderson, 20 Jordi Murphy, 21 Conor Murray, 22 Ian Madigan, 23 Noel Reid
Date: Saturday, June 14
Kick-off: 15.40 (18.40 GMT; 19.40 BST)
Venue: Estadio José Fierro, Tucumán
Referee: Pascal Gauzère (France)
Assistant referees: Glen Jackson (New Zealand), John Lacey (Ireland)
TMO: Shaun Veldsman (South Africa)