Ireland head coach Joe Schmidt will be without Keith Earls and Martin Moore for their trip to Argentina, with Noel Reid and Rodney Ah You called.
Finisher Earls has been ruled out due to illness (gastroenteritis), while prop Moore is not travelling to South America as he is nursing a fractured toe.
"Gutted not to be touring but it's been a dream first season. Thanks for the support and best of luck to the lads taking on Argentina next week," tweeted Moore, who helped Leinster with the PRO12 title.
Ireland's opening Test, at the Estadio Centenario in Resistancia, takes place on Saturday, June 7 before the two teams meet again at the Estadio José Fierro in Tucumán the following Saturday.
Ireland squad to tour Argentina
Backs (13): Darren Cave, Felix Jones, Rob Kearney, Ian Madigan, Kieran Marmion, Luke Marshall, Fergus McFadden, Conor Murray, Eoin Reddan, Noel Reid, Jonathan Sexton, Andrew Trimble, Simon Zebo.
Forwards (16): Rodney Ah You, Rory Best, James Cronin, Robbie Diack, Iain Henderson, Chris Henry, Jamie Heaslip, Rob Herring, Dave Kilcoyne, Jack McGrath, Jordi Murphy, Paul O'Connell (capt), Mike Ross, Rhys Ruddock, Devin Toner, Damien Varley.