Ireland have named Jonathan Sexton at fly-half alongside Eoin Reddan while Paul O'Connell returns for their clash with Australia in Dublin on Saturday.
O'Connell is joined at lock by Devin Toner with prop Cian Healy introduced to the front-row.
Lions and Leinster flanker Sean O'Brien starts at seven in the absence of the injured Chris Henry.
Brian O'Driscoll earns his 127th cap since his Test debut against Australia in 1999 and will be partnered in midfield by Ulster's Luke Marshall.
There are ten 2013 British and Irish Lions named in the matchday squad: Rob Kearney, Tommy Bowe, O'Driscoll, Sexton, Conor Murray, Jamie Heaslip, O'Brien, O'Connell, Rory Best and Healy.
11 of the Ireland XV started in 2011's RWC victory over the Wallabies in Eden Park, New Zealand.
Ireland: 15 Rob Kearney, 14 Tommy Bowe, 13 Brian O'Driscoll, 12 Luke Marshall, 11 Fergus McFadden, 10 Jonathan Sexton, 9 Eoin Reddan, 8 Jamie Heaslip, 7 Sean O'Brien, 6 Peter O'Mahony, 5 Paul O'Connell, 4 Devin Toner, 3 Mike Ross, 2 Rory Best, 1 Cian Healy.
Replacements: 16 Sean Cronin, 17 Jack McGrath, 18 Stephen Archer, 19 Mike McCarthy, 20 Kevin McLaughlin, 21 Conor Murray, 22 Ian Madigan, 23 Robbie Henshaw.
Date: Saturday, November 16
Kick-off: 17:45 GMT
Venue: Aviva Stadium, Dublin
Referee: Chris Pollock (New Zealand)
Assistant referees: Romain Poite (France), Stuart Berry (South Africa)
Television match official: Geoff Warren (England)
Assessor: Tappe Henning (South Africa)