Rob Webber captains England for the first time against the Barbarians at Twickenham Stadium on Sunday.
The Bath hooker leads a youthful side with 21-year-olds Matt Kvesic (Worcester Warriors) and Marland Yarde (London Irish) pulling on a senior shirt for the first time. England's starting line-up contains nine players aged 24 or under.
The replacements for the non-cap game include five more making their first appearances at this level in centre Kyle Eastmond (Bath), lock Kearnan Myall, scrum-half Haydn Thomas (Exeter Chiefs), prop Henry Thomas (Sale Sharks) and number eight Billy Vunipola (London Wasps).
"We've selected a young and exciting side and this is a great opportunity for these players who have shone in the Aviva Premiership this season to step up in front of passionate home crowd at Twickenham Stadium," said England Head Coach Stuart Lancaster.
"Taking on a very experienced Barbarians team is the first challenge they face this summer with matches in Uruguay and Argentina to follow and this sequence of games is a key part of our development as a team.
"Rob Webber finished the season strongly with Bath and I know his leadership qualities well. I am sure he'll show the way backed up by the other senior players in the team."
Meanwhile, former England international centre Mike Tindall will face his countrymen at Twickenham on Sunday after being named in the Barbarians' starting XV.
Tindall will line up alongside Casey Laulala in midfield while Welsh duo Dwayne Peel and James Hook are the half-back combination.
Young Wasps back Elliot Daly has been handed the number 15 jersey alongside impressive finishers Taku Ngwenya and Timoci Nagusa.
The pack includes French international Imanol Harinordoquy, Alessandro Zanni, Jim Hamilton, James Johnston and Andrea Lo Cicero.
Four London Wasps players have been named in the squad, with Daly joined by Jonathan Poff, Marco Wentzel and replacement Sam Jones.
England: 15 Mike Brown, 14 Christian Wade, 13 Jonathan Joseph, 12 Billy Twelvetrees, 11 Marland Yarde, 10 Freddie Burns, 9 Richard Wigglesworth, 8 Ben Morgan, 7 Matt Kvesic, 6 Tom Johnson, 5 Dave Attwood, 4 Joe Launchbury, 3 David Wilson, 2 Rob Webber, 1 Alex Corbisiero.
Replacements: 16 David Paice, 17 Joe Marler, 18 Henry Thomas, 19 Kearnan Myall, 20 Billy Vunipola, 21 Haydn Thomas, 22 Jonny May, 23 Kyle Eastmond.
Barbarians: 15 Elliot Daly, 14 Timoci Nagusa, 13 Casey Laulala, 12 Mike Tindall, 11 Taku Ngwenya, 10 James Hook, 9 Dwayne Peel, 8 Imanol Harinordoquy, 7 Jonathan Poff, 6 Alessandro Zanni, 5 Marco Wentzel, 4 Jim Hamilton, 3 James Johnston, 2 Matthew Rees, 1 Andrea Lo Cicero.
Replacements: 16 Schalk Brits, 17 Paul James, 18 Duncan Jones, 19 Dean Mumm, 20 Sam Jones, 21 Dimitri Yachvili, 22 Stephen Jones, 23 Rowan Varty.
Date: Sunday, May 26
Kick-off: 13:00 BST
Referee: Leighton Hodges (Wales)
Assistant referees: Nigel Owens (Wales), Paul Dix (England)
Television match official: David Grashoff (England)
Timekeeper: Roy Marfleet (England)
Assessor: Donal Courtney (Ireland)