London Irish hooker David Paice and Harlequins lock George Robson have been added to the England squad for the November internationals as injury cover.
The pair come into the mix after the Northampton duo of Dylan Hartley and Courtney Lawes both suffered knee injuries during the Saints' loss to Saracens on Saturday.
While the extent of the injuries to Hartley and Lawes have not yet been confirmed, Lancaster has not wasted any time in bringing in potential replacements.
Leicester's Tom Youngs is the only other hooker in the squad and Hartley's injury only adds further to Lancaster's woe, with fellow number twos Rob Webber and Joe Gray already out through injury.
Lawes missed much of last season due to an injury to his right knee but there will be some relief that the new injury is to his left knee.