Eastern Province Kings coach Carlos Spencer has made four changes to his team for Friday's clash with Western Province in Cape Town.
Dwayne Jenner takes over from Shane Gates at inside centre, while Shaun McDonald gets a chance at flank in place of Thembelani Bholi.
In other changes, prop Lizo Gqoboka returns to the front row and centre Tim Whitehead is back after suffering a knee injury.
Gqoboka replaces BG Uys, with former Springbok prop CJ van der Linde being named on the bench and Steven Sykes continues as captain in the absence of Luke Watson.
Whitehead will pair up with Jenner, while Ronnie Cooke was moved back to the wing.
Gates and Siyanda Grey, who started in the back-line against the Lions last week, are set to start on the bench.
"Shane has a slight niggle so we thought it right to give him a bit of rest, and it's good for Dwayne to get an opportunity.
"He has been training and working hard, and hopefully he will bring some physicality to the defence."
Regarding McDonald's promotion, Spencer said it was again a case of using a player who could add a robust element to their game.
"Shaun is a strong ball carrier and deserves an opportunity," explained Spencer.
"Bholi's had a lot of work in recent weeks so deserves a bit of a rest, but we will definitely use him off the bench."
Fly-half Gary van Aswegen was close to full recovery after a groin injury, but was given another week's rest.
"With George Whitehead having played flyhalf last week, it also helps to keep some stability considering the other changes we made to the back-line," added Spencer.
Eastern Province Kings: 15 Scott van Breda, 14 Ronnie Cooke, 13 Tim Whitehead, 12 Dwayne Jenner, 11 Siviwe Soyizwapi, 10 George Whitehead, 9 Kevin Luiters, 8 Aidon Davis, 7 Paul Schoeman, 6 Shaun MacDonald, 5 Steven Sykes (c), 4 David Bulbring, 3 Tom Botha, 2 Edgar Marutlulle, 1 Lizo Gqoboka.
Replacments: 16 Mike van Vuuren, 17 CJ Van der Linde, 18 Thembelani Bholi, 19 Stefan Willemse, 20 Tobie Botes, 21 Shane Gates, 22 Siyanda Grey.
Date: Friday, September 5
Kick-off: 19:10 local (18:10 BST, 17:10 GMT)
Venue: Newlands Stadium, Cape Town
Referee: Stuart Berry
Assistant referees: Quinton Immelman, Marc van Zyl
TMO: Shaun Veldsman