Peter Grant will start at fly-half, in what will be his 100th match for the Stormers, when they host the Western Force in Cape Town on Saturday.
Grant moves from inside centre to the number 10 shirt in one of five changes to the starting line-up that lost to the Bulls in Pretoria last weekend and will become just the third-ever Stormers Super Rugby centurion.
Grant follows in the footsteps of Andries Bekker (105) and Jean de Villiers (104) in playing 100 matches for the Stormers, having first played for Western Province in 2004 and making his Stormers debut in 2006.
With Grant set to join the '100-Club', prop Brok Harris will make his 200th appearance for Western Province Rugby on Saturday - having amassed 92 Stormers caps and making another 107 appearances for Western Province. Harris made his WP debut in 2006 and his Super Rugby debut for the Stormers in 2007.
Grant's shift in the back-line is one of two positional changes to the starting line-up this weekend - the other seeing Damian de Allende move from the right-wing to inside centre.
Other changes to the starting line-up to face the Force this week see the return - from injury - of lock Michael Rhodes and right wing Kobus van Wyk, whilst Deon Fourie will start at hooker in place of the injured Scarra Ntubeni.
Rhodes replaces debutant Jean Kleyn in the number four shirt, whilst Van Wyk's return out wide has allowed De Allende to move back into the midfield against the in-form Western Australian franchise.
Kleyn, meanwhile, drops to the bench this week, where he is joined by fly-half Kurt Coleman who started against the Highlanders and the Bulls.
Hooker Stephan Coetzee, prop Martin Dreyer, loose forward Siya Kolisi, scrum-half Dylon Frylinck and utility back Michael van der Spuy make up the remainder of the bench, with Frylinck still on debut should he get a run this week.
Stormers: 15 Jaco Taute, 14 Kobus van Wyk, 13 Juan de Jongh, 12 Damian de Allende, 11 Cheslin Kolbe, 10 Peter Grant, 9 Nic Groom, 8 Duane Vermeulen, 7 Schalk Burger (c), 6 Nizaam Carr, 5 Ruan Botha, 4 Michael Rhodes, 3 Pat Cilliers, 2 Deon Fourie, 1 Brok Harris.
Replacements: 16 Stephan Coetzee, 17 Alistair Vermaak, 18 Martin Dreyer, 19 Jean Kleyn, 20 Siya Kolisi, 21 Dylon Frylinck, 22 Kurt Coleman, 23 Michael van der Spuy.
Date: Saturday, May 17
Kick-off: 17:05 local (16:05 BST, 15:05 GMT)
Venue: Newlands Stadium, Cape Town
Referee: Chris Pollock (New Zealand)
Assistant referees: Marius Jonker (South Africa), Quinton Immelman (South Africa)
Television match official: Shaun Veldsman (South Africa)