Wing Eli Walker has been ruled out of what was set to be his Wales debut in their November Test opener with South Africa on Saturday.
The Ospreys wide man was injured in training on Thursday, and will be replaced by Liam Williams in the starting line-up.
Fellow Osprey, centre Ashley Beck, comes in to the replacements.
Having been ruled out of Wales' June Tests with Japan and the 2013 Six Nations through a back injury, Walker's latest problem represents yet another setback.
Wales (revised): 15 Leigh Halfpenny, 14 George North, 13 Jonathan Davies, 12 Scott Williams, 11 Liam Williams, 10 Rhys Priestland, 9 Mike Phillips, 8 Toby Faletau, 7 Sam Warburton (c), 6 Dan Lydiate, 5 Alun Wyn Jones, 4 Bradley Davies, 3 Adam Jones, 2 Richard Hibbard, 1 Gethin Jenkins.
Replacements: 16 Ken Owens, 17 Paul James, 18 Scott Andrews, 19 Luke Charteris, 20 Justin Tipuric, 21 Lloyd Williams, 22 James Hook, 23 Ashley Beck.
Date: Saturday, November 9
Kick-off: 17:30 GMT
Venue: Millennium Stadium, Cardiff
Referee: Alain Rolland (Ireland)
Assistant Referees: George Clancy (Ireland), Marius Mitrea (Italy)
TMO: Eric Gauzins (France)