Toulouse host Stade FranÃ§ais in their traditional gala clash at the end of a Top 14 weekend that could go a long way in deciding who makes the play-offs.
League leaders Toulon and Clermont both visit the Basque country, where Toulon kick the action off in Spain against Bayonne before Clermont take on Biarritz, as they prepare for their respective Heineken Cup quarter-finals in a fortnight.
The weekend's big fixture is in Paris however as fifth-placed Racing MÃ©tro host sixth placed Perpignan. Montpellier could leapfrog the losers of that battle but will need to pick up a rare win in Grenoble.
At the other end of the table, Bordeaux-BÃ¨gles have a golden opportunity to relieve their relegation worries at home to Mont-de-Marsan but Agen have no suck luck as they must travel to fortress Pierre Antoine in Castres.
Saturday, March 23
Bayonne v Toulon
Racing MÃ©tro v Perpignan
Bordeaux-BÃ¨gles v Mont-de-Marsan
Castres v Agen
Grenoble v Montpellier
Biarritz v Clermont
Sunday, March 24
Toulouse v Stade FranÃ§ais
Rugby Union betting odds
1 Toulon 76
2 Clermont 74
3 Toulouse 64
4 Castres 58
5 Racing MÃ©tro 58
6 Perpignan 55
7 Montpellier 55
8 Grenoble 48
9 Stade FranÃ§ais 46
10 Biarritz 43
11 Bayonne 41
12 Bordeaux-Begles 31
13 Agen 27
14 Mont-de-Marsan 15
Aviron Bayonnais v Rugby Club Toulonnais
Estadio de Anoeta, Saint Sebastian (Spain)
After smashing Bayonne 59-0 on home soil, Toulon will arrive in Spain full of confidence for the return leg. With five rounds left to play, RCT know another full house of points will leave them in pole position for automatic semi-final qualification.
Toulon have the league's best attack with 51 tries in 21 games and owe their two-point lead over Clermont to their bonus points. By contrast, Bayonne have scored just 18 tries this season, the second-worst record in the championship.
Toulon's French internationals Mathieu Bastareaud and FrÃ©dÃ©ric Michalak will not travel west while Rudi Wulf, Jonny Wilkinson, Matt Giteau and Bakkie Botha have been rested.
Delon Armitage makes his return from an eight-week suspension while ex-Springbok Danie Rossouw is set to make his Top 14 debut.
Bayonne welcome back Six Nations-winning scrum-half Mike Phillips but are without Gaby Lovobalavu, Cedric Garcia Neemia Tialata (suspension) and CÃ©dric Heymans.
Previous result Toulon won 59-0
Prediction: Bayonne are a different animal on home soil but they don't have much to play for. Toulon by ten points
Kick-off: 15.00 (14.00 GMT)
Referee: JÃ©rÃ´me GarcÃ¨s
Racing MÃ©tro 92 v USA Perpignan
Stade Yves Du Manoir - Colombes (Paris)
Racing MÃ©tro are enjoying an amazing run of form as they make a charge for the play-offs with an eight-game winning streak. Last week's win in Montpellier meant they are unbeaten in France in 2013.
Just three points ahead of Perpignan and five clear of Montpellier, Racing need to keep their foot on the gas to secure a place in Europe and the play-offs.
The Catalan visitors to the capital are in decent form themselves, having won their last four games and eight of their least ten. USAP also have a solid record on their visits to Colombes.
"We've been playing knock-out games every weekend for the last two months," Perpignan full-back Joffrey Michel half-joked ahead of his side's match against their direct play-off rivals.
"There's only five games left before the real play-offs. But it's exciting. Better that than finding ourselves out of the running."
Racing welcome back French internationals Luc Ducalcon and Maxime Machenaud as well as full-back GaÃ«tan Germain. Wing Benjamin Fall and Juan Imhoff, loose forward Bernard Le Roux and prop Andrea Lo Cicero are injured.
Perpignan have included their Bleus Nicolas Mas, SÃ©bastien Vahaamahina and Romain Taofifenua.
Previous result: Perpignan won 17-13
Prediction: USAP are in great form but it's tough to bet against racing at the moment. Racing MÃ©tro by less than seven points
Kick-off: 18:45 (17.45 GMT)
Referee: Patrick GaÃ¼zere
Union Bordeaux-BÃ¨gles v Stade Montois
Stade Jacques Chaban-Delmas, Bordeaux
Just four points clear of the relegation zone, Bordeaux-BÃ¨gles cannot afford to slip up at home against a side that will surely get the chop.
Never have both promoted clubs managed to retain their places in the Top 14 and, in contrast to Grenoble, Mont-de-Marsan look set to confirm that trend.
Les Montois won the last two games between these sides, but those were in the Challenge Cup. In domestic action, UBB have won the last six clashes between these teams.
Previous result: Bordeaux-BÃ¨gles won 17-12
Prediction: UBB look like a solid bet, but it won't be pretty. Bordeaux-BÃ¨gles by six points
Kick-off: 18:45 (17.45 GMT)
Referee: Christophe Berdos
Castres Olympique v SU Agen
Stade Pierre Antoine, Castres
Agen travel to one of the most difficult places to visit in France in desperate need of a result. Stuck in the drop zone, Les Agenais have a very tough end-of-season schedule including games against Clermont, Perpignan and Toulon.
The bad news for Saturday's visitors to Stade Pierre Antoine is that they have lost on their last three visits to the Tarn and Castres have lost just once at home this season (to Toulouse).
Castres were beaten in Clermont last week but are in good form having toppled Toulon and Montpellier in their two previous games.
The hosts will be without flank Ibrahim Diarra and fly-half Dan Kirkpatrick but welcome back Romain Teulet.
Agen are missing fly-half Raphael Lagarde and wing Nafi Tuitavake but have been bolstered by the return of full-back Silvere Tian.
Previous result: Castres won 22-14
Prediction: The hosts should win comfortably. Casttes by fifteen points
Kick-off: 18:45 (17.45 GMT)
Referee: Salem Attalah
FC Grenoble v Montpellier HÃ©rault Rugby
Stade LesdiguiÃ¨res, Grenoble
Montpellier have slipped out of the play-offs places after consecutive defeats (to Castres and Racing) and are in danger of missing out on the knock-out stages for the first time in three years.
Grenoble, for so long untouchable at home and the surprise package of the season, have gone off the boil, losing their last three games and five of their last six.
The hosts have lost just once in 11 home matches this season though - to Clermont - so will fancy their chances of