Harlequins are unchanged from last week's semi-final win over Bath for the LV=Cup Final against Sale Sharks on Sunday.
There is one change among the replacements, which sees James Johnston coming in for Kyle Sinckler who is away with the England U20s in Wales.
14 of the match day squad lifted the Aviva 'A' League title in December, while 15 are under 23 years of age.
Meanwhile, after losing 28-34 in the opening group game at London Irish, Sale have gone on to beat Saracens twice, Wasps at Adams Park and Scarlets at the Salford City Stadium to reach the final for the first time.
Sunday is the first time Sale Sharks have played in a major final since May 2006 when they beat Leicester Tigers in the Premiership Final at Twickenham.
Sale have used 45 players in reaching the final with Tony Buckley, Danny Cipriani, Ross Harrison and Tommy Taylor featuring in every game so far. Sale have scored 17 tries in the competition so far with Danny Cipriani top try scorer with three. Cipriani has scored 64 points in all which is just two behind leader Ben Botica of Quins.
Harlequins: 15 Ross Chisholm, 14 Tom Williams, 13 George Lowe, 12 Tom Casson, 11 Sam Smith, 10 Ben Botica, 9 Karl Dickson, 8 Tom Guest, 7 Luke Wallace (c), 6 Maurie Fa'asavalu, 5 Charlie Matthews, 4 Sam Twomey, 3 Will Collier, 2 Rob Buchanan, 1 Mark Lambert.
Replacements: 16 Dave Ward, 17 Darryl Marfo, 18 James Johnston, 19 Pete Browne, 20 Joe Trayfoot, 21 Jordan Burns, 22 Rory Clegg, 23 Charlie Walker.
Sale Sharks: 15 Nick Macleod, 14 Tom Brady, 13 Will Addison, 12 Johnny Leota, 11 Charlie Ingall, 10 Danny Cipriani, 9 Nathan Fowles, 8 Andy Powell, 7 David Seymour (c), 6 James Gaskell, 5 Tom Holmes, 4 Fraser McKenzie, 3 Tony Buckley, 2 Marc Jones, 1 Al Dickinson.
Replacements: 16 Tommy Taylor, 17 Ross Harrison, 18 Henry Thomas, 19 Andrei Ostrikov, 20 Daniel Braid, 21 Dwayne Peel, 22 Sammy Tuitipou, 23 Mark Cueto.
Date: Sunday, March 16
Referee: Greg Garner (England)