Ireland fly-half Jonathan Sexton and lock Mike McCarthy have been ruled out of next weekend's Six Nations match against Scotland in Edinburgh.
The duo sustained injuries in last weekend's home loss to England with Sexton limping off with an injured hamstring and lock Mike McCarthy suffering knee ligament damage.
Ireland team manager Mick Kearney revealed that neither will recover in time for the game at Murrayfield on February 24.
"Jonny's scan revealed a grade two hamstring injury," he said.
"Progress has been good so far, but it's too early to say when he will return to play.
"Mike has hurt the medial ligament of his right knee. It's quite sore and he will be in a brace for two weeks. A further review will take place in two weeks."