Wales interim head coach Rob Howley has selected youngster Tavis Knoyle ahead of Mike Phillips for Saturday's clash with Argentina at the Millennium Stadium.
The 22-year-old Scarlet has been in impressive form for his region lately and gets a chance at scrum-half with Phillips dropping to the replacements' bench.
Aaron Jarvis will make his Wales debut in the place of Lions prop Adam Jones, who is recovering from knee trouble, while flanker Josh Turnbull makes his second start for his country in place of ankle injury victim Dan Lydiate.
Another Scarlet, Scott Williams, starts at centre instead of his club-mate Jonathan Davies, who has failed to shake off the groin problem he sustained against Clermont in time.
Perpignan playmaker James Hook will be hoping to see some action from the bench alongside young full-back Liam Williams, while the likes of Justin Tipuric, Paul James and Rob McCusker provide forwards cover.
"One or two injuries have forced our hand in certain areas in terms of selection but the fact that we are still able to field a side packed with Grand Slam experience shows that we have been able to develop some depth in recent years," said Howley.
Wales: 15 Leigh Halfpenny, 14 Alex Cuthbert, 13 Scott Williams, 12 Jamie Roberts, 11 George North, 10 Rhys Priestland, 9 Tavis Knoyle, 8 Toby Faletau, 7 Sam Warburton (c), 6 Josh Turnbull,5 Ian Evans, 4 Alun Wyn Jones,3 Aaron Jarvis, 2 Matthew Rees, 1 Gethin Jenkins.
Replacements: 16 Richard Hibbard, 17 Ryan Bevington, 18 Paul James, 19 Rob McCusker, 20 Justin Tipuric, 21 Mike Phillips, 22 James Hook, 23 Liam Williams.
Date: Saturday, 10 November
Venue: Millennium Stadium
Kick-off: 14:30 GMT
Referee: Romain Poite (France)
Assistant referees: George Clancy (Ireland), Dudley Phillips (Ireland)
Television match official: Jim Yuille (Scotland)