Western Province coach Allister Coetzee has included flanker Tyrone Holmes in his starting XV for Saturday's clash with the Sharks in Durban.
Holmes returns in the number seven jersey, after recovering from a shoulder injury, and he will replace Rynhardt Elstadt who has, in turn, been ruled out for three weeks with a rib injury.
The inclusion of Holmes is the only change to the run-on side that beat the Free State Cheetahs in bloemfontein last weekend.
On the bench, meanwhile, Tom Botha replaces Springbok squad member Frans Malherbe as the additional front row replacement and fit-again Joe Pietersen returns to the matchday 22 at the expense of youngster Pat Howard.
Botha is a former WP U21 stalwart and a member of the Vodacom Cup-winning WP side from earlier this year. He will make his Currie Cup debut should he take to the field.
Pietersen will return to action for the first time since Round One - also against the Sharks - a wrist injury having kept him out.
"This is a good Sharks side - even without their many Springboks," said Coetzee.
"Their pack then (when we lost to them in the first round) was probably weaker than the one now - they've got Bresler back and Daniel too. Really, they're a quality outfit across the board," said Coetzee.
"Also, it's an away game (in Durban), which is another challenge for us, plus we've not beaten the Sharks in the 2012 Currie Cup.
"Every game is important and tough, but we want to start the second round of competition better and we want to continue improving our game."
Western Province:15 Gio Aplon, 14 Gerhard van den Heever, 13 JP du Plessis, 12 Marcel Brache, 11 Damian de Allende, 10 Demetri Catrakilis, 9 Nic Groom, 8 Jebb Sinclair, 7 Tyrone Holmes, 6 Deon Fourie (c), 5 De Kock Steenkamp, 4 Don Armand, 3 Brok Harris, 2 Siyabonga Ntubeni, 1 Deon Carstens.
Replacements:16 Steven Kitshoff, 17 Tom Botha, 18 Wilhelm van der Sluys, 19 Helmut Lehmann, 20 Louis Schreuder, 21 Kurt Coleman, 22 Joe Pietersen.
Date: Saturday, September 15
Venue: Kings Park Stadium, Durban
Kick-off: 19.10 (18.10 BST, 17.10 GMT)
Referee: Lourens van der Merwe
Assistant referees: Jaco van Heerden, Reuben Rossouw
TMO: Shaun Veldsman