Australia centre Digby Ioane was on Friday ruled out of Saturday's November international against Scotland with a shoulder injury.
The 24-year-old Queensland star has suffered a shoulder injury and is replaced in the starting line-up by Western Force's Ryan Cross.
The injury is to Ioane's right shoulder, rather than the left which required reconstruction earlier this year and sidelined him for six months.
Lachlan Turner takes Cross' place on the bench, meaning the Wallabies have now made two changes from Sunday's 20-20 draw in Ireland.
Australia: revised 15 Adam Ashley-Cooper, 14 Peter Hynes, 13 Ryan Cross, 12 Quade Cooper, 11 Drew Mitchell, 10 Matt Giteau, 9 Will Genia, 8 Wycliff Palu, 7 George Smith, 6 Rocky Elsom (c), 5 Mark Chisholm, 4 James Horwill, 3 Ben Alexander, 2 Stephen Moore, 1 Benn Robinson.
Replacements: 16 Tatafu Polota-Nau, 17 Sekope Kepu, 18 Dean Mumm, 19 Richard Brown, 20 Luke Burgess, 21 Lachie Turner, 22 James O'Connor.
Date: Saturday, November 21
Venue: Murrayfield
Kick-off: 17.15 GMT
Referee: Romain Poite (France)
Assistant referees: Nigel Owens (Wales), Jérôme Garces (France)
Television match officials: Graham Hughes (England)
Assessor: Tappe Henning (South Africa)
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