History will be made on Friday when Benetton Treviso become the first Italian team to play at Murrayfield in the Magners League.
Edinburgh head coach Rob Moffat has urged his men to mark the occasion with a third straight home domestic win.
The capital club have seen off Leinster and Ulster in the last two Magners League matches played in the Scotland capital, and also emerged victorious from the clash with Treviso's Italian counterparts Aironi in Viadana last month.
Moffat, who has made a number of alterations to his starting line-up in the wake of last week's single-point defeat at the RDS, has backed this new-look side to make the right sort of first impression against their visitors from the Veneto.
"We've been doing well at home in the Magners League of late, and we all really want another win to keep up that positive momentum," he said.
"After the Treviso game, we won't play again until Connacht [at Murrayfield on Friday 26 November], so it's vital we have the right sort of platform to set ourselves for the rest of the season.
"Against Leinster last Saturday, we let ourselves down in a few areas, and with the changes we've made to the team, a number of guys now have an opportunity to help us produce a better performance and result."
Nine players who didn't run out in Dublin will be involved from the off on Friday.
Prop David Young makes his first start of the season at tighthead in an all-new front row where Kyle Traynor and Andrew Kelly also feature.
Fraser McKenzie resumes service in the second row after being withdrawn from the Leinster game on the morning of the match because he was suffering from a sore back. Alan MacDonald, the other returning face in the pack, will start at blindside flanker.
Behind the scrum, Greig Laidlaw and David Blair will partner one another at half-back, the latter having recovered from the head knock that kept him away from the field last weekend.
John Houston retains his place in midfield, but will have Ben Cairns as his sidekick this time around. Mark Robertson will start on the wing, with Jim Thompson moving to full-back.
Meanwhile, Italian lock Gonzalo PadrÃ² is set to make his first official appearance in the green and white jersey for Treviso, while centre Andrea Pratichetti could do it as well but he is starting from the bench.
Edinburgh: 15 Jim Thompson, 14 Mark Robertson, 13 Ben Cairns, 12 John Houston, 11 Tim Visser, 10 David Blair, 9 Greig Laidlaw, 8 Netani Talei, 7 Roddy Grant (c), 6 Alan MacDonald, 5 Fraser McKenzie, 4 Scott MacLeod3 David Young, 2 Andrew Kelly, 1 Kyle Traynor.
Replacements: 16 Finlay Gillies, 17 Geoff Cross, 18 Lewis Niven, 19 Craig Hamilton, 20 Scott Newlands, 21 Ross Samson, 22 Alex Grove, 23 Lee Jones.
Treviso: 15 Brendan Williams, 14 Ludovico Nitoglia, 13 Ezio Galon, 12 Gonzalo Garcia, 11 Benjamin De Jager, 10 Kristopher Burton, 9 Tobias Botes, 8 Marco Filippucci, 7 Benjamin Vermaak, 6 Enrico Pavanello, 5 Corniel Van Zyl, 4 Gonzalo PadrÃ², 3 Pedro Di Santo, 2 Franco Sbaraglini (c), 1 Augusto Allori.
Replacements: 16 Enrico Ceccato, 17 Matteo Muccignat, 18 Ignacio Fernandez Rouyet, 19 Valerio BernabÃ², 20 Robert Barbieri, 21 Francesco Minto, 22 Fabio Semenzato, 23 Andrea Pratichetti.
Date: Friday, 5 November
Kick-off: 19:05 GMT
Referee: Leighton Hodges (Wales)
Assistant Referees: Andy Macpherson (Scotland), Archie McInally (Scotland)