Second plays third in the Top 14 on Friday as Round 17 of the competition kicks-off with an intriguing showdown between Stade FranÃ§ais and Castres.
Friday's fixture at Stade Jean Bouin sees the return of league action following a two-week break due to Heineken Cup and Challenge Cup rugby.
Both of these two went into the break on the back of wins, as Stade FranÃ§ais beat Biarritz 18-6 while Castres edged past Bordeaux-BÃ¨gles 15-9.
The hosts include number eight Sergio Parisse, with the international and club skipper set to be watched nervously by Italy boss Jacques Brunel.
Parisse is accompanied in the back-row by Pierre Rabadan and Scott Lavalla while Gerhard Mostert and Anton van Zyl will form the lock partnership.
Australia and former Reds wing Digby Ioane must settle for a place on the replacements bench for this clash, as does Jules Plisson, with Waisea Vuidarvuwalu and Julian Arias occupying the wing berths while MornÃ© Steyn is named fly-half. The Springbok wears number ten alongside scrum-half Julien Dupuy.
Castres suffered a blow this week when winger Romain Martial sustained a dislocated left shoulder, which will soon need operating on. Returning to the side, however, will be scrum-half Rory Kockott while lock Richie Gray starts and fellow Scot Max Evans is on the bench.
Stade FranÃ§ais: 15 Hugo Bonneval, 14 Waisea Vuidarvuwalu, 13 Geoffrey Doumayrou, 12 Meyer Bosman, 11 Julian Arias, 10 MornÃ© Steyn, 9 Julien Dupuy, 8 Sergio Parisse (capt), 7 Pierre Rabadan, 6 Scott Lavalla, 5 Gerhard Mostert, 4 Anton van Zyl, 3 David Attoub, 2 Remi Bonfils, 1 Heinke van der Merwe.
Replacements: 16 Michael Van Vuuren, 17 Zak Taulafo, 18 Carl Weger, 19 David Lyons, 20 Jerome Fillol, 21 Jules Plisson, 22 Digby Ioane, 23 Davit Kubriashvili.
Castres: 15 Geoffrey Palis, 14 Marcel Garvey, 13 Romain Cabannes (c), 12 Remi Lamerat, 11 Remi Grosso, 10 Daniel Kirkpatrick, 9 Rory Kockott, 8 Piula Faasalele, 7 Yannick Caballero, 6 Ibrahim Diarra, 5 Rodrigo Capo Ortega, 4 Richie Gray, 3 Karena Wihongi, 2 Brice Mach, 1 Saimone Taumoepeau.
Replacements: 16 Mathieu Bonello, 17 Mihaita Lazar, 18 Benjamin Desroches, 19 Janni Bornman, 20 Cedric Garcia, 21 Seremaia BaÃ¯, 22 Max Evans, 23 Anton Peikrishvili.
Result in Round 4: Castres 38-10 Stade FranÃ§ais
Venue: Stade Jean Bouin, Paris
Kick-off: 20.45 (19.45 GMT)
Referee: Laurent Cardona