The Newport Gwent Dragons will be without the services of Steffan Jones and Darren Waters for the foreseeable future.
Jones dislocated his elbow during Cross Keys' pre-season friendly against Coventry and has undergone surgery on the injury. He will be out of action for eight to 12 weeks as a result.
The Dragons have fly-half cover in the form of Italy international Kris Burton and Jason Tovey.
Waters ruptured knee ligaments in training and will be sidelined for at least four to five months after going under the knife. It's a bitter blow for the flanker who suffered the same injury against London Irish last year and went on to make only two appearances for the Dragons last term as a result.
"It's a devastating injury for Darren because he was looking really good in pre-season training," team manager Robert Beale told the South Wales Argus.
"It was such an innocuous injury and it such a disappointment after he suffered such cruel luck last season.
"But Darren is a tough kid and is optimistic that he can make a quick recovery, just like he did last year when his determination meant he came back ahead of schedule."