Dom Shipperley will make his Wallaby debut against South Africa on Saturday while Kurtley Beale has been recalled at full-back.
Reeling from two defeats in as many weekends to New Zealand, under-fire Australian coach Robbie Deans announced a starting XV on Tuesday that features three changes in personal and one positional switch for a game that will see Stephen Moore become the most capped hooker in Australian Test history.
21-year-old Shipperley boasts exceptional pace and Deans, who is under pressure to turn around their fortunes or face the sack, will hope he can inject some urgency into a team humiliated 22-0 by the All Blacks at Eden Park.
With the versatile Adam Ashley-Cooper reverting to centre for the 30th time in his now 69-Test career, Beale is back in the starting XV after being benched for the last match.
The mercurial Quade Cooper has also been included in the side, with the flyhalf recovering from a small leg-bone fracture.
As expected, winger Drew Mitchell has been ruled out with a ruptured ankle tendon. Among others missing injured are David Pocock, James Horwill, James O'Connor, Sekope Kepu, Wycliff Palu, Pat McCabe and Ben McCalman.
Elsewhere, number eight Radike Samo returns to the Test starting pack for the first time this year, with Scott Higginbotham relocating to the bench.
Moore is set to become the most capped hooker in Australian Test history when he takes the field in Perth, moving past Jeremy Paul's tally of 72 appearances.
The 29-year-old made his debut against Samoa at Sydney in 2005.
Australia: 15 Kurtley Beale, 14 Dominic Shipperley, 13 Adam Ashley-Cooper, 12 Berrick Barnes, 11 Digby Ioane, 10 Quade Cooper, 9 Will Genia (c), 8 Radike Samo, 7 Michael Hooper, 6 Dave Dennis, 5 Nathan Sharpe, 4 Sitaleki Timani, 3 Ben Alexander, 2 Stephen Moore, 1 Benn Robinson.
Replacements: 16 Tatafu Polota Nau, 17 James Slipper, 18 Scott Higginbotham, 19 Liam Gill, 20 Nick Phipps, 21 Mike Harris, 22 Anthony Fainga'a.
Date: Saturday, September 8
Venue: Patersons Stadium, Perth
Kick-off: 18.35 (10.35 GMT)
Referee: Nigel Owens (Wales)