The Sharks have lost centre Francois Steyn and number eight Lubabalo Mtembu for the remainder of their tour due to injuries.
Both players were forced off the field during Saturday's 25-22 loss to the Highlanders in Dunedin, with Steyn suffering a suspected broken leg and Mtembu a damaged shoulder.
The setback is a cruel blow for the Sharks, who now have a shocking amount of injured playes on their casualty list.
And to make matters worse, the Round 12 defeat was the Durban-based side's fourth straight loss after winning five of their first six games.
"Our injury situation is not good. Our backs are decimated," said coach John Plumtree.
"We've just got to keep going. We've got to get some fit guys organised in time and just get on with it."
Plumtree didn't criticise his side for turning down late penalty shots which could have drawn the game. Instead they pushed for what would have been a winning try and failed as the Highlanders ended an 11-match losing streak dating back to May last year.
"The boys wanted to get four points. Time was up on the clock and we wouldn't have had time to get back down into their territory and win the game," Plumtree said.
"It's disappointing. We looked good when we had the ball and kept it but we had too many little opportunities that we didn't nail.
"You can't doubt the boys' effort but the changing room is a mess."