The Sharks have been dealt two major injury blows after loose forwards Jean Deysel and Jacques Botes were both ruled out for up to four weeks, coach John Plumtree confirmed on Tuesday.
Deysel was replaced early in their Super Rugby match against the Kings after suffering a ligament injury to his ankle, while Botes, who had come on to replace him, has a suspected cracked wrist.
"It's not good news for us and hopefully it's not worse," said Plumtree.
"He'll (Deysel) have another scan tomorrow to determine that."
However, the Sharks boss did confirm that captain Keegan Daniel is fit again after his knee injury and could feature against the top-of-the-table Brumbies in Durban on Saturday.
"Keegan trained really hard with us this morning and hopefully he'll be able to return this week, which will ease a little bit of the pain," said Plumtree.