The Reds have named veteran back-row Radike Samo at number eight for their Super Rugby clash with the Stormers at Newlands on Saturday.
The Fijian cult hero will make his long-awaited return to the Reds line-up for what will be just his third match of the season and first since coming off the bench in the 23-13 victory over the Rebels.
Injuries have limited Samo to just 30 minutes of Super Rugby in 2013 but he has since returned to peak fitness and form through strong efforts in the Queensland Premier Rugby competition for GPS.
His inclusion at eight marks just the second time this year that the back-row combination of Eddie Quirk, Liam Gill and Jake Schatz has been broken with rising star Jarrad Butler replacing the then-injured Gill in the Reds 23-18 win over the Bulls.
Schatz moves to blindside flanker and Quirk to the bench in a gameday squad which also features talented ball scavenger and replacement Beau Robinson.
In the backs, 22-year-old Jono Lance has regained his place at fullback after missing last weekend's match against the Cheetahs with a shoulder problem and will see Luke Morahan shift to the wing in place of injured flyer Digby Ioane.
"Eddie has done a brilliant job for us in starting every game so far this season but Radike will bring a new dimension to the way we play and is also a fresh body to further energise the group following what has been a long stretch of matches," said boss Ewen McKenzie.
"We're nearing the end of what has been an extremely demanding period, where we've played 15 games during the past 16 weeks. As such, anytime you get the chance to freshen up and bring new faces into the group at this time of the season is always beneficial.
"We also know the attributes Radike brings to the game, especially with his ball running, and that can only be advantageous against a Stormers team which has conceded the fewest number of tries in the competition to date."
The match will be the Reds' final regular-season contest against an international opponent and they will also be determined to end their two-game South African campaign on a high note following their recent loss to the Cheetahs in Bloemfontein.
In their last visit to Cape Town in 2011, the Reds produced one of their best performances of the season to topple the South African heavyweights 19-6 at Newlands Stadium on their way to winning their maiden Super Rugby championship in the professional Rugby era.
Reds: 15 Jono Lance, 14 Rod Davies, 13 Chris Feauai-Sautia, 12 Anthony Faingaa, 11 Luke Morahan, 10 Quade Cooper, 9 Will Genia, 8 Radike Samo, 7 Liam Gill, 6 Jake Schatz, 5 James Horwill (c), 4 Rob Simmons, 3 James Slipper, 2 Saia Faingaa, 1 Greg Holmes.
Replacements: 16 James Hanson, 17 Ben Daley, 18 Ed O'Donoghue, 19 Eddie Quirk, 20 Beau Robinson, 21 Ben Lucas, 22 Ben Tapuai.
Date: Saturday, May 25
Venue: Newlands Stadium, Cape Town
Kick-off: 17.05 (15.05 GMT)
Referee: Jaco Peyper (South Africa)
Assistant Referees: Quinton Immelman (South Africa), Marc van Zyl (South Africa)
Television match official: Shaun Veldsman (South Africa)