Chiefs utility back Tim Nanai-Williams will play on the wing when the defending champions host the Reds in Hamilton on Saturday.
Nanai-Williams, who missed the Chiefs' last match against the Blues through injury, has impressed at outside centre in previous matches this season.
His return is one of three changes to coach Dave Rennie's starting XV.
Ben Tameifuna starts at prop with Michael Fitzgerald retaining his position at lock while Craig Clarke edges closer to a return.
The loose forward trio of Sam Cane, Tanerau Latimer and Liam Messam start, with Messam captaining the side from the number eight position.
Fritz Lee is amongst the replacements and he is joined by prop Michael Kainga who gets a chance to play his first Super Rugby match off the bench.
Rennie expects a difficult assignment against 2011's champions.
"The Reds are a high quality side that has got some world class players," he said.
"I have been impressed by what I saw of them against the Highlanders.
"We got toweled up against them last year so it is going to be a hell of a challenge."
Chiefs: 15 Gareth Anscombe, 14 Tim Nanai Williams, 13 Richard Kahui, 12 Bundee Aki, 11 Asaeli Tikoirotuma, 10 Aaron Cruden, 9 August Pulu, 8 Liam Messam (c), 7 Sam Cane, 6 Tanerau Latimer, 5 Brodie Retallick, 4 Michael Fitzgerald, 3 Ben Tameifuna, 2 Hika Elliot, 1 Toby Smith.
Replacements: 16 Rhys Marshall, 17 Michael Kainga, 18 Nick Crosswell, 19 Fritz Lee, 20 Brendon Leonard, 21 Andrew Horrell, 22 Patrick Osborne.
Date: Saturday, 13 April
Venue: Waikato Stadium, Hamilton
Kick-off: 16:35 (04:35 GMT)
Referee: Steve Walsh (Australia)