The Bulls have named their side that will face the Brumbies in their Super Rugby semi-final, with Jan Serfontein and Francois Hougaard both starting.
The duo's return coincides with former Junior Springbok lock Paul Willemse returning to take his place on the bench for Saturday's clash.
All three players recovered from the injuries that kept them out of the last league fixture against the Stormers in Cape Town two weeks ago.
Serfontein replaces Francois Venter in the midfield and Hougaard's inclusion comes at the expense of Jano Vermaak, who will move to the bench, where he replaces Rudy Paige.
Willemse replaces Jacques du Plessis, who made his debut in Cape Town.
"We have worked hard to put ourselves in a position where we could host a semifinal at home and achieved that. We cannot allow all that effort to go to waste on Saturday," Ludeke said.
"We certainly respect the Brumbies as an opponent, but this match will be about us and our ability and drive to make them play the game at our tempo and to our game plan. For that we will need to be accurate and execute the big plays well."
Bulls captain Dewald Potgieter encouraged the home supporters to help them over the line.
"We have great fans and we love doing well in front of them. It is going to be a game of margins on Saturday and if we have our support base behind us, we will be able to edge ahead. We have to play the right type of rugby at the right times in the match and I am confident of that. We have experience in play-offs and we have big game players, so we will be ready," Potgieter said.
Bulls: 15 Zane Kirchner, 14 Akona Ndungane, 13 JJ Engelbrecht, 12 Jan Serfontein, 11 Bjorn Basson, 10 Mornč Steyn, 9 Francois Hougaard, 8 Dewald Potgieter (c), 7 Jacques Potgieter, 6 Deon Stegmann, 5 Grant Hattingh, 4 Flip van der Merwe, 3 Werner Kruger, 2 Chiliboy Ralepelle, 1 Dean Greyling.
Replacements: 16 Callie Visagie, 17 Frik Kirsten, 18 Mornč Mellett, 19 Paul Willemse, 20 Jono Ross, 21 Jano Vermaak, 22 Jürgen Visser.
Date: Saturday, July 27
Kick-off: 17:05 (15:05 GMT)
Venue: Loftus Versfeld, Pretoria, South Africa
Referee: Craig Joubert
Assistant referees: Jaco Peyper, Stuart Berry
TMO: Shaun Veldsman