The Brumbies bounced back with maximum points from last week's loss to go top of the Aussie conference after demolishing the Rebels 37-6 in Canberra on Saturday.
A first-half blitz by the Brumbies laid the platform for a crucial bonus-point victory with the game pretty much over at half-time thanks to the home side's 30-6 lead.
The win is a big boost for Jake White's troops ahead of their two-week tour of South Africa, while another Rebels loss will undoubtedly ask questions of the Melbourne side, who have conceded their fifth defeat of the season and also their eighth straight defeat while on the road.
The Brumbies dominated territory and possession from the outset and were rewarded with two Christian Lealiifano penalties in the opening 10 minutes.
The visitors hardly touched the ball in the early stages but they struck back after 15 minutes with a massive 53 metre penalty from former England fly-half Danny Cipriani.
But the Brumbies responded immediately when inside centre Pat McCabe brushed aside fellow Wallaby James O'Connor to score under the posts.
O'Connor replied with a penalty, only for the Brumbies to seize control with tries for flanker Michael Hooper and lock Scott Fardy, both coming from sloppy defending around the edge of the rucks.
Things went from bad to worse for the Rebels when skipper Gareth Delve was shown a yellow card for persistent offences.
During his 10 minutes off the field the Brumbies scored a fourth try when skipper Ben Mowen steamed onto an inside ball from McCabe to touch down beside the posts.
The Rebels were far more committed in the second half and tried hard to break down the Brumbies defence, but a series of unforced errors continually handed the advantage back to the home side.
The Brumbies absorbed everything the Rebels threw at them, then had the final say when Fardy crashed over for his second try.
Tries: McCabe, Hooper, Fardy 2, Mowen
Cons: Lealiifano 2
Pens: Lealiifano 2
Pens: Cipriani, O'Connor
Brumbies: 15 Jesse Mogg, 14 Joe Tomane, 13 Tevita Kuridrani, 12 Pat McCabe, 11 Henry Speight, 10 Christian Lealiifano, 9 Nic White, 8 Fotu Auelua, 7 Michael Hooper, 6 Ben Mowen (capt), 5 Sam Carter, 4 Scott Fardy, 3 Dan Palmer, 2 Stephen Moore, 1 Ruaidri Murphy.
Replacements: 16 Anthony Hegarty, 17 Ben Alexander, 18 Peter Kimlin, 19 Ita Vaea, 20 Ian Prior, 21 Robbie Coleman, 22 Andrew Smith.
Melbourne Rebels: 15 Kurtley Beale, 14 Lachlan Mitchell, 13 Mitch Inman, 12 James O'Connor, 11 Mark Gerrard, 10 Danny Cipriani, 9 Nick Phipps, 8 Gareth Delve (c), 7 Jarrod Saffy, 6 Luke Jones, 5 Hugh Pyle, 4 Al Campbell, 3 Rodney Blake, 2 Ged Robinson, 1 Nic Henderson.
Replacements: 16 Luke Holmes, 17 Eddie Aholelei, 18 Michael Lipman, 19 Tim Davidson, 20 Richard Kingi, 21 Julian Huxley, 22 Lloyd Johansson.
Referee: Craig Joubert (South Africa)