Wales interim head coach Rob Howley has quelled speculation by naming the same starting XV that won in Paris last weekend.
The move means that flanker Sam Warburton and lock Alun Wyn Jones will have to start from the bench after returning from injury.
Wales will once again be lead by flanker Ryan Jones, who replaced Warburton for the victory over France.
Alun Wyn Jones only returned from injury last Friday in a 30 minute appearance for the Ospreys in their win over Ulster.
"I have told the players the same XV will start in Italy," said Howley.
"I think it is pretty important from a coach's perspective that we reward the players who have gone out on the field.
"I thought Ryan Jones was outstanding in terms of his leadership and it is a just reward that he captains the side against Italy."