Wales are sweating over the fitness of hooker Richard Hibbard and versatile forward Ryan Jones heading into the upcoming Six Nations Championship.
The duo are looking like joining the Grand Slam holders' long injury list after both were forced off during their Heineken Cup draw with Leicester.
Jones dislocated his thumb and was replaced after 33 minutes while Hibbard then went off holding a shoulder following winning a penalty.
"He dislocated his thumb and I think the bone may have popped out as well," Ospreys coach Steve Tandy told BBC Sport.
"We'll review that on Monday but it doesn't look good for him though."
Wales and Scarlets centre Scott Williams also left the field prematurely on Saturday while Cardiff Blues lock Bradley Davies has been ruled out for several weeks with an ankle ligament problem.
Wales kick-off their Six Nations title defence at home to Ireland on February 2.