Sergio Parisse will captain Italy in their clash with England on Sunday as coach Jacques Brunel makes several changes to his side.
Parisse returns at number eight to partner Robert Barbieri in the back row, with Brunel making seven changes in total to the side that were defeated 26-9 by Wales in Rome.
Joshua Furno and Quintin Geldenhuys form a new lock pairing, with Alberto de Marchi at loosehead prop and Andrea Lo Cicero dropping to the bench.
Luciano Orquera is restored to the starting line-up at fly-half, replacing Kristopher Burton.
Gonzalo Canale and Gonzalo Garcia will form a new-look centre pairing, with Tommaso Benvenuti dropping to the bench.
Italy: 15 Andrea Masi, 14 Giovambattista Venditti, 13 Gonzalo Canale, 12 Gonzalo Garcia, 11 Luke McLean, 10 Luciano Orquera, 9 Edoardo Gori, 8 Sergio Parisse, 7 Robert Barbieri, 6 Alessandro Zanni, 5 Joshua Furno, 4 Quintin Geldenhuys, 3 Martin Castrogiovanni, 2 Leonardo Ghiraldini (c) 1 Alberto De Marchi.
Replacements: 16 Davide Giazzon, 17 Andrea Lo Cicero, 18 Lorenzo Cittadini, 19 Antonio Pavanello, 20 Francesco Minto, 21 Simone Favaro, 22 Tobias Botes, 23Tommaso Benvenuti.
Date: Sunday, 10 March
Kick-off: 15:00 GMT
Referee: George Clancy (Ireland)
Assistant referees: Nigel Owens (Wales), Mathieu Raynal (France)
Television match official: Simon McDowell (Ireland)