Ireland back Fergus McFadden has been ruled out of Saturday's Six Nations clash against Italy with rib damage.
Ireland's injury woes continue unabated as Leinster centre McFadden, who started on the wing against France in Dublin, joins Eoin Reddan (broken leg) on the sidelines.
The Irish camp are hopeful that Jonathan Sexton and Craig Gilroy could return for the trip to Rome but Brian O'Driscoll (dead leg), Luke Marshall (concussion), Donnacha Ryan (shoulder) are doubts.
Conor Murray (knee) and Peter O'Mahony (dead leg) were also injured in last Saturday's 13-13 draw but both are expected to be fit for Ireland's final game of the Championship.
Ulster scrum-half Paul Marshall is the likely replacement for Reddan.
Ireland's campaign had been plagued by injury from the outset but head coach Declan Kidney insists on maintaining a positive frame of mind.
"We took a conscious decision that we would not complain about things," he said.
"Other people are worse off than we are, plus it is such an insult to the lads coming on and having a huge go.
"We are frustrated, but there are lads coming in who have no experience at this level under their belts and are doing such a good job for us.
"On any given day Paul O'Connell, Tommy Bowe, Stephen Ferris and Jonathan Sexton would be in the running for a Lions spot.
"I have never experienced an injury run like this, but you work your way through and I spoke to Jamie Heaslip about it and we agreed not (to) complain."