France coach Philippe Saint-André has made seven changes and one positional change to his starting XV to face England at Twickenham.
Wesley Fofana is moved from the wing to partner Mathieu Bastareaud in the centre, with Vincent Clerc taking his place on the right wing after being recalled.
Morgan Parra and Francois Trinh-Duc will form a new half-back pairing, with Frederic Michalak and Maxime Machaneaud named on the bench.
In the forwards, Thomas Domingo and Benjamin Kayser will form a new-look front row alongside Nicolas Mas, with Christophe Samson coming in at second row to replace Jocelino Suta who is amongst the replacements.
The final change sees Yannick Nyanga form an all-Toulouse back-row alongside club team-mates Thierry Dusautoir, who captains the side, and Louis Picamoles.
South African-born number-eight Antoine Claassen could make his debut from the bench.
France: 15 Yoann Huget, 14 Vincent Clerc, 13 Mathieu Bastareaud, 12 Wesley Fofana, 11 Benjamin Fall, 10 Francois Trinh-Duc, 9 Morgan Parra, 8 Louis Picamoles, 7 Thierry Dusautoir, 6 Yannick Nyanga, 5 Yoann Maestri, 4 Christophe Samson, 3 Nicolas Mas, 2 Benjamin Kayser, 1 Thomas Domingo.
Replacements: 16 Dimitri Szarzewski, 17 Vincent Debaty, 18 Luc Ducalcon, 19 Jocelino Suta, 20 Antoine Claassen, 21 Maxime Machenaud, 22 Frederic Michalak, 23 Florian Fritz.
Referee: Craig Joubert (South Africa)
Assistant referees: John Lacey (Ireland), Leighton Hodges (Wales)
Television match official: Jim Yuille (Scotland)