England coach Stuart Lancaster has made three changes to play France, with Manu Tuilagi, Dylan Hartley and Courtney Lawes returning.
Tuilagi is reunited with Brad Barritt in the centres with Billy Twelvetrees dropping to the bench. Hartley replaced Tom Youngs at hooker, whilst Lawes swaps in for James Haskell who is on the bench.
"We thought long and hard about changing a winning team which did so well against Ireland," said Lancaster.
"But we believe that Dylan, Courtney and Manu are ready for the opportunity and allow us to vary our play, while the bench will add impact and energy as the game unfolds in the second half.
"The players are really looking forward to getting back to Twickenham; the atmosphere in the stadium is fantastic and hopefully the crowd can get behind us in what is sure to be a great challenge against a motivated and physical French team."
England: 15 Alex Goode, 14 Chris Ashton, 13 Manu Tuilagi, 12 Brad Barritt, 11 Mike Brown, 10 Owen Farrell, 9 Ben Youngs, 8 Tom Wood, 7 Chris Robshaw (c), 6 Courtney Lawes, 5 Geoff Parling, 4 Joe Launchbury, 3 Dan Cole, 2 Dylan Hartley, 1 Joe Marler.
Replacements: 16 Tom Youngs, 17 David Wilson, 18 Mako Vunipola, 19 Thomas Waldrom, 20 James Haskell, 21 Danny Care, 22 Toby Flood, 23 Billy Twelvetrees.
Referee: Craig Joubert (South Africa)
Assistant referees: John Lacey (Ireland), Leighton Hodges (Wales)
Television match official: Jim Yuille (Scotland)